Dihydro-orotate Dehydrogenase (DHODH) is one type of flavo-enzyme. It catalyse the oxydation of Dihydro-orotate (DHO) to the orotate (ORO) as part of fourth and rate limiting step of ‘de novo’ pyrimidine biosynthetic pathway. It has been proven that the DHODH inhibitors having efficacy for the treatment of Cancer, Malaria and Immunological disorder. This 2-D QSAR studies were performed by using software ChemDraw Ultra-8.0, Openbable-2.2.1, Dragon and Valstat. The value of Q2 for model-1 is 0.718091 and R2 value is 0.77607 and for model-2 Q2 = 0.71141 and R2 = 0.769419. Both models were validated by help of Valstat software.
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